Presentation Title: The Vision of 21st Century Medicine: Big Data, Longitudinal Deep Phenotyping and Scientific Wellness
Dr. Leroy Hood presented this talk in the webinar on Materials Science, Engineering and Technology organized by Vebleo
Affiliation:
1Cofounder, Professor and Chief Strategy Officer Institute for Systems Biology, Seattle WA, USA
2Senior Vice President and Chief Science Officer Providence St. Joseph Health, Seattle WA, USA
Biography
Dr. Leroy Hood received an MD from Johns Hopkins Medical School and a PhD from Caltech. He was a professor at Caltech for 22 years; a co-founder and chairman of the first cross-disciplinary biology department of Molecular Biotechnology at the University of Washington Medical School for 8 years; a co-founder and president for 18 years of the Institute for Systems Biology—the first systems biology institution.
Dr. Leroy Hood is in the US National Academies of Science, Medicine and Engineering—one of only 10 to be so honored. He invented the automated DNA sequencer that made the human genome sequence possible and 5 other instruments that serve collectively as the technological foundations of contemporary biology and molecular biology.
Dr. Leroy Hood has published more than 900 papers, has 36 patents and 18 honorary degrees from leading institutions all over the world. He has published textbooks on biochemistry, immunology, molecular immunology, genetics and is just finishing a text on systems biology. He has won many national and international awards including the Lasker Award, the Kyoto Prize and the National Medal of Science.
Dr. Leroy Hood has co-founded 16 biotech companies including Amgen, Applied Biosystems, Rosetta and Arivale. He is pioneering systems-driven 21st century medicine—which will transform contemporary healthcare into a predictive, preventive, personalize and participatory medicine.
Abstract
21st century medicine is undergoing a revolution that argues healthcare should be predictive, preventive, personalized and participatory (P4) and acknowledges it has two major domains—wellness and disease. The effective implementation of P4 healthcare arises from the idea that the complexity of human biology and the complexity of disease can only be assessed in each individual with genomic and deep phenotypic analyses (e.g., blood analytes, gut microbiome, digital health measurements, etc).
Thus 21st century medicine is about following longitudinally the health trajectory of each individual and optimizing wellness and detecting and avoiding transitions to disease. I will report on the analyses of longitudinal deep phenotyping data from about 5000 well individuals from Arivale—a company bringing quantitative or scientific wellness to consumers that closed down about 9 months ago.
I will also talk about a new proposal that we are just initiating to implement genomic and deep phenotyping analyses on 1-million patients (the million person project) at Providence St. Joseph Health (PSJH), the 3rd largest healthcare non-profit institute over a 5 year period—this project will be the catalyst for achieving 21st century medicine and will bring this new approach to approximately 10% of the PSJH patients.
It offers unique possibilities for improving clinical service, the possibility to discover thousands of new actionable possibilities, each of which can improve health, from the integration of genomic and phenomic data, the possibility of creating a myriad of new companies (e.g., new data generation assays, AI for managing for physicians the thousands of actionable possibilities, novel computational platforms for integration and analyses, etc.).
It will be the ultimate manifestation of scientific (or quantitative) wellness. It turns out that 21st century medicine will give us powerful new approaches to solving contemporary medicine’s four largest challenges: improving quality of health care, reducing its costs, leading us to age in a healthy manner (to deal with the large aging population), and provide us with an approach to ending most chronic disease by early prediction and prevention. I will discuss all of these issues and more.
Graphical Abstract
This talk was delivered in the webinar organized by Vebleo