Presentation Title: Plasmonic metamaterials for ultrasensitive biosensing
Prof. Andrei Kabashin presented this talk in the webinar on Nanomedicine, Nanomaterials and Nanotechnology organized by Vebleo
Affiliation: 1) Aix Marseille University, CNRS, LP3, Campus de Luminy – Case 917, 13009, Marseille, France
2) MEPhI”, Institute of Engineering Physics for Biomedicine (PhysBio), Bionanophotonic Lab., 115409 Moscow, Russia
Biography
Prof. Andrei Kabashin is one of world-leading experts in optical biosensing/imaging and laser-ablative synthesis of nanomaterials for biomedical applications. Prof. Andrei Kabashin obtained his Master Degree from Moscow Institute of Physics and Technology (MIPT, Technical University), Moscow, Russia in 1989 and Ph.D. degree from A.M. Prokhorov General Physics Institute, Moscow, Russia in 1994.
From 1999 to 2008 Prof. Andrei Kabashin worked as a Research Professor in Ecole Polytechnique de Montreal at the University of Montreal, Canada. Since 2009 Prof. Andrei Kabashin has held a Research Director position of the French National Center of Scientific Research (CNRS) in Aix-Marseille University, Marseille, France.
Prof. Andrei Kabashin is also a scientific supervisor of Institute of Engineering Physics for Biomedicine and of International Laboratory “Bionanophotonics” in MEPHI, Moscow, Russia, as well as holding faculty positions in the Institute of Lasers, Photonics and Biophotonics in State University of New York at Buffalo (USA) and the University of Sherbrooke (Canada).
Abstract
Relying on the control of interactions between a target analyte (antigen, protein, DNA etc) and its receptor (antibody, ligand, DNA capture etc.) immobilized on the gold surface via refractive index (RI) monitoring, plasmonic biosensing is a leading technology for label-free monitoring of biological binding events with a variety of applications in biomedicine, food and environmental safety, security.
Based on the excitation of propagating surface plasmon polaritons over a thin gold film, Surface Plasmon Resonance (SPR) has formed the core of plasmonic biosensing technology, providing a dominating majority of studies. An extension of SPR, called localized plasmon resonance (LPR), is realized by using metallic nanostructures. The detection limit of SPR and LPR in terms of resolvable surface coverage of biomaterial is of the order of 1 pg/mm2 and 1 ng/mm2, respectively, which makes possible label-free studies of many interactions, but still inferior to labeling methods by more than 2 orders of magnitude.
Our project is aimed at the improvement of sensitivity and cost-efficiency of plasmonic biosensors. To address the sensitivity issue, we recently introduced the concept of “plasmonic metamaterial for biosensing”, which was defined as “artificial material, composed of nanoscale gold blocks (metaatoms), arranged in a lattice, which can provide a much improved response compared to natural materials (Au, Au) and/or enable new functionalities”.
One of metamaterial geometries is based on gold nanorods, oriented perpendicularly to the glass substrate, which makes possible the excitation of a new guided “G” mode, whose sensitivity (>30000 nm of spectral shift per RI unit change) outperforms all LPR and SPR biosensors. Plasmonic nanoparticle arrays enabling Surface Lattice Resonances (SLRs) present another example of such a metamaterial, providing extremely narrow (2-3 nm FWHM) and deep resonant features, leading to singularities of light phase.
The employment of such singularities in phase-sensitive schemes opens up access to single molecule label-free detection. Other important biosensor architectures include 3D plasmon metamaterials and phase-responsive Fourier nanotransducers. As an example, the latter concept makes possible the detection of antibiotic chloramphenicol at fg·mL−1 level, which is at least 3 orders of magnitude better than reported in the literature for all label-based and label-free counterparts.
The presentation will describe novel designs of plasmonic metamaterial-based biosensors, as well present innovative miniaturized designs of plasmonic biosensor
Graphical Abstract
This talk was delivered in the webinar organized by Vebleo